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Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
《医学前沿(英文)》 2008年 第2卷 第2期 页码 195-199 doi: 10.1007/s11684-008-0037-7
关键词: chemotactic activity receptor uPA inhibitor F10 chemoattractant
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 112-120 doi: 10.1007/s11705-021-2075-5
关键词: fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients
《医学前沿(英文)》 doi: 10.1007/s11684-023-0997-7
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 99-105 doi: 10.1007/s11783-013-0490-7
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
《医学前沿(英文)》 2008年 第2卷 第1期 页码 51-57 doi: 10.1007/s11684-008-0010-5
关键词: antitumor therapy occurrence implantation DNA vaccine SART3 DNA
Molecular dynamic simulation on the conformation of mouse muscle type nAChR
Shengai SUN, Rilei YU, Yanhui ZHANG, Yanni LI,
《化学科学与工程前沿(英文)》 2010年 第4卷 第3期 页码 348-352 doi: 10.1007/s11705-009-0284-4
关键词: pentameric hydrophilic Tyr127 cryoelectron microscopic conformation
Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 330-335 doi: 10.1007/s11684-016-0459-6
The enhancer of zeste 2 polycomb repressive complex 2 subunit (Ezh2) is a histone-lysine N-methyltransferase enzyme that participates in DNA methylation. Ezh2 has also been reported to play crucial roles in stem cell proliferation and differentiation. However, the detailed expression profile of Ezh2 during mouse cochlear development has not been investigated. Here, we examined the spatiotemporal expression of Ezh2 in the cochlea during embryonic and postnatal development. Ezh2 expression began to be observed in the whole otocyst nuclei at embryonic day 9.5 (E9.5). At E12.5, Ezh2 was expressed in the nuclei of the cochlear prosensory epithelium. At E13.5 and E15.5, Ezh2 was expressed from the apical to the basal turns in the nuclei of the differentiating cochlear epithelium. At postnatal day (P) 0 and 7, the Ezh2 expression was located in the nuclei of the cochlear epithelium in all three turns and could be clearly seen in outer and inner hair cells, supporting cells, the stria vascularis, and spiral ganglion cells. Ezh2 continued to be expressed in the cochlear epithelium of adult mice. Our results provide the basic Ezh2 expression pattern and might be useful for further investigating the detailed role of Ezh2 during cochlear development.
关键词: polycomb repressive complex Ezh2 expression inner ear cochlea development
《医学前沿(英文)》 2022年 第16卷 第6期 页码 919-931 doi: 10.1007/s11684-021-0918-6
关键词: preeclampsia recombinant protein diannexin microparticle NLRP3 inflammasome phosphatidylserin
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
《医学前沿(英文)》 2009年 第3卷 第2期 页码 141-147 doi: 10.1007/s11684-009-0041-6
孟庆刚,朱士恩,曾申明,张忠诚
《中国工程科学》 2001年 第3卷 第11期 页码 65-69
论述了一种新的小鼠卵母细胞去核方法一一表面张力辅助去核法(STA),并同时与其他3种去核方 法(简称A法、B法、C法)进行比较。STA法是将卵母细胞核在固定管的辅助下,借助液体表面张力通过透 明带上的破口被挤出。经STA法去核的卵母细胞质体用于电融合介导的小鼠耳成纤维细胞核移植实验,结果有 76.1 %细胞与细胞质体融合形成重组胚,85.4 %的重组胚形成原核,49.4%卵裂形成2-细胞。
《医学前沿(英文)》 2022年 第16卷 第6期 页码 873-882 doi: 10.1007/s11684-022-0925-2
关键词: Salmonella VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis
Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts
Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 379-383 doi: 10.1007/s11684-009-0073-y
关键词: p38 regulated/activated protein kinase gene knockout cell cycle cell proliferation
《医学前沿(英文)》 2023年 第17卷 第3期 页码 458-475 doi: 10.1007/s11684-022-0968-4
关键词: LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous SNP GPI-anchored protein
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 266-276 doi: 10.1007/s11684-017-0530-y
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.
关键词: postnatal HFD feeding obesity kisspeptin HPG axis precocious puberty
R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome
《医学前沿(英文)》 2022年 第16卷 第6期 页码 932-945 doi: 10.1007/s11684-022-0963-9
关键词: Gitelman syndrome mouse model compound heterozygous hypokalemia Slc12a3
标题 作者 时间 类型 操作
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
期刊论文
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
期刊论文
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
期刊论文
Antitumor immunity of human SART3 gene vaccine against mouse tumor
HE Yu, YANG Shuhua, LIU Yong, LI Tao
期刊论文
Molecular dynamic simulation on the conformation of mouse muscle type nAChR
Shengai SUN, Rilei YU, Yanhui ZHANG, Yanni LI,
期刊论文
Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing
期刊论文
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
期刊论文
Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse
期刊论文
Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts
Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,
期刊论文
domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse
期刊论文
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a
null
期刊论文